Last lines from
The Maltese Falcon, which was directed by John Huston and released in 1941:
Detective Tom Polhaus: [picks up the falcon] Heavy. What is it?
Sam Spade: The, uh, stuff that dreams are made of.
Polhaus: Huh?
This film is full of snappy lines brilliantly delivered by Humphrey Bogart in his role as protagonist "Samuel Spade," but that insightful line of his (above) is my favorite film-ending line of all time.
=^..^=